Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis infects over 10 million people annually and kills more people each year than any other human pathogen. The current tuberculosis (TB) vaccine is only partially effective in preventing infection, while current TB treatment is problematic in terms of length, complexity and patient compliance. There is an urgent need for new drugs to combat the burden of TB disease and the natural environment has re-emerged as a rich source of bioactive molecules for development of lead compounds. In this study, one species of marine sponge from the Tedania genus was found to yield samples with exceptionally potent activity against M. tuberculosis. Bioassay-guided fractionation identified bengamide B as the active component, which displayed activity in the nanomolar range against bot

SUBMITTER: Quan DH 

PROVIDER: S-EPMC6779907 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature