History of Migraine and Volume of Brain Infarcts: The Italian Project on Stroke at Young Age (IPSYS).

ABSTRACT:

Background and purpose

Migraine has been shown to increase cerebral excitability, promote rapid infarct expansion into tissue with perfusion deficits, and result in larger infarcts in animal models of focal cerebral ischemia. Whether these effects occur in humans has never been properly investigated.

Methods

In a series of consecutive patients with acute ischemic stroke, enrolled in the setting of the Italian Project on Stroke at Young Age, we assessed acute as well as chronic infarct volumes by volumetric magnetic resonance imaging, and compared these among different subgroups identified by migraine status.

Results

A cohort of 591 patients (male, 53.8%; mean age, 37.5±6.4 years) qualified for the analysis. Migraineurs had larger acute infarcts than non-migraineurs (m

SUBMITTER: De Giuli V 

PROVIDER: S-EPMC6780016 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature