Vitamin D Deficiency is Associated with Increased Disease Activity in Patients with Inflammatory Bowel Disease.

ABSTRACT: Vitamin D has an inhibitory role in the inflammatory signaling pathways and supports the integrity of the intestinal barrier. Due to its immunomodulatory effect, vitamin D plays a role in chronic inflammatory bowel disease (IBD) and a deficiency is associated with an increased risk for a flare. We aimed to investigate to what extent the 25-hydroxyvitamin D (25(OH)D3) level correlates with disease activity and whether a cut-off value can be defined that discriminates between active disease and remission. Patients with IBD, treated at the University Hospital Frankfurt were analyzed retrospectively. The 25(OH)D3 levels were correlated with clinical activity indices and laboratory chemical activity parameters. A deficiency was defined as 25(OH)D3 levels <30 ng/mL. A total of 470 (257 female) p

SUBMITTER: Hausmann J 

PROVIDER: S-EPMC6780251 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature