Divergent Copies of a Cryptosporidium parvum-Specific Subtelomeric Gene.

ABSTRACT: Subtype families of Cryptosporidium parvum differ in host range, with IIa and IId being found in a broad range of animals, IIc in humans, and IIo and IIp in some rodents. Previous studies indicated that the subtelomeric cgd6_5520-5510 gene in C. parvum is lost in many Cryptosporidium species, and could potentially contribute to the broad host range of the former. In this study, we identified the presence of a second copy of the gene in some C. parvum subtype families with a broad host range, and showed sequence differences among them. The sequence differences in the cgd6_5520-5510 gene were not segregated by the sequence type of the 60 kDa glycoprotein gene. Genetic recombination appeared to have played a role in generating divergent

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6780254 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature