[Beneficial effect of periodontal therapy on insulin resistance and lipid metabolism in obese rats with periodontitis].

ABSTRACT: OBJECTIVE:To investigate the effect of periodontal therapy in controlling periodontitis and on insulin resistance and lipid metabolism in obese rats with periodontitis. METHODS:Sprague-Dawley rats were randomized into normal group (group C), obese group (group O), periodontitis combined with obesity group (group P) and periodontal treatment group (group T). The obese rats in groups P and T were subjected to ligation of the maxillary second molar with silk thread to induce experimental periodontitis, and the rats in group T received periodontal therapy after the ligation. All the rats were sacrificed at the age of 24 weeks for measurement of blood lipids, insulin and blood glucose levels, and insulin resistance index (HOMA-IR) was calculated. The expressions of insulin receptor substrate-1

SUBMITTER: Chai QX 

PROVIDER: S-EPMC6780471 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature