Long Non-Coding RNAs Modulate Sjogren's Syndrome Associated Gene Expression and Are Involved in the Pathogenesis of the Disease.

ABSTRACT: Primary Sjögren's syndrome (pSjS) is a chronic systemic autoimmune disorder, primarily affecting exocrine glands; its pathogenesis is still unclear. Long non-coding RNAs (lncRNAs) are thought to play a role in the pathogenesis of autoimmune diseases and a comprehensive analysis of lncRNAs expression in pSjS is still lacking. To this aim, the expression of more than 540,000 human transcripts, including those ascribed to more than 50,000 lncRNAs is profiled at the same time, in a cohort of 16 peripheral blood mononuclear cells PBMCs samples (eight pSjS and eight healthy subjects). A complex network analysis is carried out on the global set of molecular interactions among modulated genes and lncRNAs, leading to the identification of reliable lncRNA-miRNA-gene functional interactions. Taking t

SUBMITTER: Dolcino M 

PROVIDER: S-EPMC6780488 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature