Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan.

ABSTRACT: Malignant glioma (MG) is a poor prognostic brain tumor with inevitable recurrence after multimodality treatment. Searching for more effective treatment is urgently needed. Differentiation induction via epigenetic modification has been proposed as a potential anticancer strategy. Natural products are known as fruitful sources of epigenetic modifiers with wide safety margins. We thus explored the effects of oligo-fucoidan (OF) from brown seaweed on this notion in MG cells including Grade III U87MG cells and Grade IV glioblastoma multiforme (GBM)8401 cells and compared to the immortalized astrocyte SVGp12 cells. The results showed that OF markedly suppress the proliferation of MG cells and only slightly affected that of SVGp12 cells. OF inhibited the protein expressions of DNA methyltransfera

SUBMITTER: Liao CH 

PROVIDER: S-EPMC6780514 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature