Nitric Oxide Donor Modulates a Multispecies Oral Bacterial Community-An In Vitro Study.

ABSTRACT: The deterioration of human oral microbiota is known to not only cause oral diseases but also to affect systemic health. Various environmental factors are thought to influence the disruption and restoration of the oral ecosystem. In this study, we focused on the effect of nitric oxide (NO) produced by denitrification and NO synthase enzymes on dental plaque microbiota. Interdental plaques collected from 10 subjects were exposed to NO donor sodium nitroprusside (SNP) and then cultured in a specialized growth medium. Depending on the concentration of exposed SNP, a decrease in α-diversity and a continuous change in β-diversity in the dental plaque community were shown by sequencing bacterial 16S rRNA genes. We also identified eight operational taxonomic units that were significantly altered b

SUBMITTER: Nambu T 

PROVIDER: S-EPMC6780529 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature