Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface.

ABSTRACT: Nanomedicine has generated significant interest as an alternative to conventional cancertherapy due to the ability for nanoparticles to tune cargo release. However, while nanoparticletechnology has promised significant benefit, there are still limited examples of nanoparticles inclinical practice. The low translational success of nanoparticle research is due to the series ofbiological roadblocks that nanoparticles must migrate to be effective, including blood and plasmainteractions, clearance, extravasation, and tumor penetration, through to cellular targeting,internalization, and endosomal escape. It is important to consider these roadblocks holistically inorder to design more effective delivery systems. This perspective will discuss how nanoparticlescan be designed to migrate each of the

SUBMITTER: Simpson JD 

PROVIDER: S-EPMC6780590 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature