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New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae).

ABSTRACT: Three new 8-hydroxybriaranes-fragilides R-T (1-3) were obtained from a sea whip gorgonian coral Junceella fragilis. The structures of briaranes 1-3 were elucidated by using spectroscopic methods, including 1D (1H and 13C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (2 and 3) are the only briaranes known to possess 8?-hydroxy and 17?-methyl groups, respectively. Briarane 2 exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.

SUBMITTER: Chen YY 

PROVIDER: S-EPMC6780648 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Three new 8-hydroxybriaranes-fragilides R-T (<b>1</b>-<b>3</b>) were obtained from a sea whip gorgonian coral <i>Junceella fragilis</i>. The structures of briaranes <b>1</b>-<b>3</b> were elucidated by using spectroscopic methods, including 1D (<sup>1</sup>H and <sup>13</sup>C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (<b>2</b> and <b>3</b>) are the only briaranes known to possess 8α-hydroxy and 17β-methyl groups, respectively. Briarane <  ...[more]

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