Aptamer-Functionalized Liposomes as a Potential Treatment for Basal Cell Carcinoma.

ABSTRACT: More than one out of every three new cancers is a skin cancer, and the large majority are basal cell carcinomas (BCC). Targeted therapy targets the cancer's specific genes, proteins, or tissue environment that contributes to cancer growth and survival and blocks the growth as well as the spread of cancer cells while limiting damage to healthy cells. Therefore, in the present study AS1411 aptamer-functionalized liposomes for the treatment of BCC were obtained and characterized. Aptamer conjugation increased liposome size, suggesting that the presence of an additional hydrophilic molecule on the liposomal surface increased the hydrodynamic diameter. As expected, the negatively charged DNA aptamer reduced the surface potential of the liposomes. Vertical Franz diffusion cells with artificial m

SUBMITTER: Cadinoiu AN 

PROVIDER: S-EPMC6780726 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature