Hepatocellular Carcinoma: Molecular Mechanisms and Targeted Therapies.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors worldwide. HCC is a complex process that is associated with several etiological factors, which in turn result in aberrant activation of different cellular and molecular pathways and the disruption of balance between activation and inactivation of protooncogenes and tumor suppressor genes, respectively. Since HCC most often occurs in the setting of a diseased or cirrhotic liver and most of the patients are diagnosed at the late stage of disease, prognosis is generally poor. At present, limited treatment options with marginal clinical benefits are available. Systemic therapy, particularly in the form of conventional cytotoxic drugs, are generally ineffective. In recent years, molecular-targeted therapies hav

SUBMITTER: Alqahtani A 

PROVIDER: S-EPMC6780754 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature