Embryonic FAP⁺ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes.

ABSTRACT: The induction of adaptive immunity is dependent on the structural organization of LNs, which is in turn governed by the stromal cells that underpin LN architecture. Using a novel fate-mapping mouse model, we trace the developmental origin of mesenchymal LN stromal cells (mLNSCs) to a previously undescribed embryonic fibroblast activation protein-α (FAP)⁺ progenitor. FAP⁺ cells of the LN anlagen express lymphotoxin β receptor (LTβR) and vascular cell adhesion molecule (VCAM), but not intercellular adhesion molecule (ICAM), suggesting they are early mesenchymal lymphoid tissue organizer (mLTo) cells. Clonal labeling shows that FAP⁺ progenitors locally differentiate into mLNSCs. This process is also coopted in nonlymphoid tissues in response to infection to fa

SUBMITTER: Denton AE 

PROVIDER: S-EPMC6780995 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature