Resident memory CD8 T cells persist for years in human small intestine.

ABSTRACT: Resident memory CD8 T (Trm) cells have been shown to provide effective protective responses in the small intestine (SI) in mice. A better understanding of the generation and persistence of SI CD8 Trm cells in humans may have implications for intestinal immune-mediated diseases and vaccine development. Analyzing normal and transplanted human SI, we demonstrated that the majority of SI CD8 T cells were bona fide CD8 Trm cells that survived for >1 yr in the graft. Intraepithelial and lamina propria CD8 Trm cells showed a high clonal overlap and a repertoire dominated by expanded clones, conserved both spatially in the intestine and over time. Functionally, lamina propria CD8 Trm cells were potent cytokine producers, exhibiting a polyfunctional (IFN-γ⁺ IL-2⁺ TNF-α^+</

SUBMITTER: Bartolome-Casado R 

PROVIDER: S-EPMC6781004 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature