Probabilities of Multilocus Genotypes in SIB Recombinant Inbred Lines.

ABSTRACT: Recombinant Inbred Lines (RILs) are obtained through successive generations of inbreeding. In 1931 Haldane and Waddington published a landmark paper where they provided the probabilities of achieving any combination of alleles in 2-way RILs for 2 and 3 loci. In the case of sibling RILs where sisters and brothers are crossed at each generation, there has been no progress in treating 4 or more loci, a limitation we overcome here without much increase in complexity. In the general situation of L loci, the task is to determine 2 L probabilities, but we find that it is necessary to first calculate the 4 L "identical by descent" (IBD) probabilities that a RIL inherits at each locus its DNA from one of the four originating chromosomes. We show that these 4 L probabilities satisfy a system of line

SUBMITTER: Jebreen K 

PROVIDER: S-EPMC6781035 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature