Enhancing genetic disease control by selecting for lower host infectivity and susceptibility.

ABSTRACT: Infectious diseases have a huge impact on animal health, production and welfare, and human health. Understanding the role of host genetics in disease spread is important for developing disease control strategies that efficiently reduce infection incidence and risk of epidemics. While heritable variation in disease susceptibility has been targeted in livestock breeding, emerging evidence suggests that there is additional genetic variation in host infectivity, but the potential benefits of including infectivity into selection schemes are currently unknown. A Susceptible-Infected-Recovered epidemiological model incorporating polygenic genetic variation in both susceptibility and infectivity was combined with quantitative genetics selection theory to assess the non-linear impact of genetic sel

SUBMITTER: Tsairidou S 

PROVIDER: S-EPMC6781107 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature