Early-life DNA methylation profiles are indicative of age-related transcriptome changes.

ABSTRACT:

Background

Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions are observed with brain aging and can be prevented by anti-aging interventions, but the relationship of altered methylation to gene expression is poorly understood.

Results

Paired analysis of the hippocampal methylome and transcriptome with aging of male and female mice demonstrates that age-related differences in methylation and gene expression are anti-correlated within gene bodies and enhancers. Altered promoter methylation with aging was found to be generally un-related to altered gene expression. A more striking relation

SUBMITTER: Hadad N 

PROVIDER: S-EPMC6781367 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature