Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Gonzalez NA
PROVIDER: S-EPMC6781432 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
The Journal of cell biology 20190903 10
How mammalian cells regulate their physical size is currently poorly understood, in part due to the difficulty in accurately quantifying cell volume in a high-throughput manner. Here, using the fluorescence exclusion method, we demonstrate that the mechanosensitive transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are regulators of single-cell volume. The role of YAP/TAZ in volume regulation must go beyond its influence on total ...[more]