Distinct expression and prognostic value of OTU domain-containing proteins in non-small-cell lung cancer.

ABSTRACT: The ubiquitin-proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor-associated proteases domain-containing proteins (OTUDs), as a subfamily within the DUB family, serve an important role in regulatory mechanisms of several biological processes, through the regulation of gene transcription, cell cycle, immune response, inflammation and tumor growth processes, and may be important in the diagnosis of various diseases and constitute novel drug targets. However, the role of OTUDs in non-small-cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the Oncomine da

SUBMITTER: Deng J 

PROVIDER: S-EPMC6781715 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature