Genetic Signatures of Drug Response Variability in Drosophila melanogaster.

ABSTRACT: Knowledge of the genetic basis underlying variation in response to environmental exposures or treatments is important in many research areas. For example, knowing the set of causal genetic variants for drug responses could revolutionize personalized medicine. We used Drosophila melanogaster to investigate the genetic signature underlying behavioral variability in response to methylphenidate (MPH), a drug used in the treatment of attention-deficit/hyperactivity disorder. We exposed a wild-type D. melanogaster population to MPH and a control treatment, and observed an increase in locomotor activity in MPH-exposed individuals. Whole-genome transcriptomic analyses revealed that the behavioral response to MPH was associated with abundant gene expression alterations. To confirm the

SUBMITTER: Rohde PD 

PROVIDER: S-EPMC6781897 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature