Thrombin generation measurement using the ST Genesia Thrombin Generation System in a cohort of healthy adults: Normal values and variability.

ABSTRACT:

Background

Thrombin generation (TG) assays evaluate the balance between pro- and anticoagulant forces, to better assess bleeding and thrombotic risks. Although TG readouts obtained with the calibrated automated TG have been investigated in multiple clinical conditions, TG still needs standardization and clinical validation. The automated TG instrument ST Genesia® (STG, Stago, Asnières-sur-Seine, France) provides a normalization of TG parameters based on a reference plasma aiming to reduce the interlaboratory variability and the variability between different measurement runs.

Objectives

To evaluate STG in a group of healthy adults.

Methods

Reference intervals in healthy adults and variability of the new standardized reagents for bleeding (BleedScreen) and thrombophilic

SUBMITTER: Calzavarini S 

PROVIDER: S-EPMC6781929 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature