The Aplysia mytilus inhibitory peptide-related peptides: identification, cloning, processing, distribution, and action.

ABSTRACT: Neuropeptides are a ubiquitous class of signaling molecules. In our attempt to understand the generation of feeding behavior in Aplysia, we have sought to identify and fully characterize the neuropeptides operating in this system. Preliminary evidence indicated that Mytilus inhibitory peptide (MIP)-like peptides are present and operating in the circuitry that generates feeding in Aplysia. MIPs were originally isolated from the bivalve mollusc Mytilus edulis, and related peptides have been identified in other invertebrate species, but no precursor has been identified. In this study, we describe the isolation and characterization of novel Aplysia MIP-related peptides (AMRPs) and their precursor. Several AMRPs appear to have some structural and functional features similar to vertebrate opioid

SUBMITTER: Fujisawa Y 

PROVIDER: S-EPMC6782896 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature