Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis.

ABSTRACT:

Background

Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more evidence-based information.

Methods

Four online databases, PubMed, Embase, Web of Science, and China Biology Medicine disc (CBM), were searched in August 2018. An odds ratio (OR) with a 95% confidence interval (CI) was applied to evaluate the association of the rs1800872 with periodontitis susceptibility.

Results

Twenty three case-control studies with 2714 patients and 2373 healthy controls were evaluated. The overall analyses verified that the IL-10 rs1800872 polymorphism was s

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6783189 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature