Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.

ABSTRACT: Motivations intensify over hours or days, promoting goals that are achieved in minutes or hours, causing satiety that persists for hours or days. Here we develop Drosophila courtship as a system to study these long-timescale motivational dynamics. We identify two neuronal populations engaged in a recurrent excitation loop, the output of which elevates a dopamine signal that increases the propensity to court. Electrical activity within the recurrent loop accrues with abstinence and, through the activity-dependent transcription factor CREB2, drives the production of activity-suppressing potassium channels. Loop activity is decremented by each mating to reduce subsequent courtship drive, and the inhibitory loop environment established by CREB2 during high motivation slows the reaccumulation o

SUBMITTER: Zhang SX 

PROVIDER: S-EPMC6783369 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature