T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4⁺ T Regulatory Cell Activity In Vivo following Transplantation.

ABSTRACT: The T cell-specific adaptor protein (TSAd), encoded by the SH2D2A gene, is an intracellular molecule that binds Lck to elicit signals that result in cytokine production in CD4⁺ T effector cells (Teff). Nevertheless, using Sh2d2a knockout (KO; also called TSAd^-/-) mice, we find that alloimmune CD4⁺ Teff responses are fully competent in vivo. Furthermore, and contrary to expectations, we find that allograft rejection is accelerated in KO recipients of MHC class II-mismatched B6.C-H-2^bm12 heart transplants versus wild-type (WT) recipients. Also, KO recipients of fully MHC-mismatched cardiac allografts are resistant to the graft-prolonging effects of costimulatory blockade. Using adoptive transfer models, we find that KO T regulatory cells (Tr

SUBMITTER: Wedel J 

PROVIDER: S-EPMC6783373 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature