Rodent ketamine depression-related research: Finding patterns in a literature of variability.

ABSTRACT: Discovering that the anesthetic drug ketamine has rapidly acting antidepressant effects in many individuals with major depression is one of the most important findings in clinical psychopharmacology in recent decades. The initial report of these effects in human subjects was based on a foundation of rodent preclinical studies carried out in the 1990s, and subsequent investigation has included both further studies in individuals with depression, as well as reverse translational experiments in animal models, especially rodents. While there is general agreement in the rodent literature that ketamine has rapidly-acting, and generally sustained, antidepressant-like properties, there are also points of contention across studies, including the precise mechanism of action of this drug. In this rev

SUBMITTER: Polis AJ 

PROVIDER: S-EPMC6783386 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature