SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus.

ABSTRACT: Systemic lupus erythematosus (SLE) impacts multiple organ systems, although the causes of many individual SLE pathologies are poorly understood. This study was designed to elucidate organ-specific inflammation by identifying proteins that correlate with SLE organ involvement and to evaluate established biomarkers of disease activity across a diverse patient cohort. Plasma proteins and autoantibodies were measured across seven SLE manifestations. Comparative analyses between pathologies and correlation with the SLE Disease Activity Index (SLEDAI) were used to identify proteins associated with organ-specific and composite disease activity. Established biomarkers of composite disease activity, SLE-associated antibodies, type I interferon (IFN), and complement C3, correlated with composite SLE

SUBMITTER: Smith MA 

PROVIDER: S-EPMC6783423 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature