Association between high-density lipoprotein cholesterol and all-cause mortality in the general population of northern China.

ABSTRACT: Recent studies proposed reasonable doubts about the good prognosis of very high levels of high-density lipoprotein cholesterol (HDL-c). We aimed to investigate the association between HDL-c levels and all-cause mortality using data from an observational cohort study in northern China from 2006 to 2015. The study population was stratified into six groups by HDL-c levels in mg/dl (<40, 40-49, 50-59, 60-69, 70-79, ≥80). Cox hazards regression models were used to estimate the association between HDL-c levels and all-cause mortality. In total, 100,070 participants (aged 51.9 ± 12.7 years) were included in the current analysis. During a mean follow-up of 8.76 years, 7,362 deaths were identified (mortality rate, 8.40 per 1000 person-years). There was a significant interaction effect between age a

SUBMITTER: Li X 

PROVIDER: S-EPMC6783426 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature