Metabolic output defines Escherichia coli as a health-promoting microbe against intestinal Pseudomonas aeruginosa.

ABSTRACT: Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli producing these acids is debatable. Taking a Koch's postulates approach in reverse, we define Escherichia coli as health-promoting for naturally colonizing the gut of healthy mice and protecting them against intestinal colonization and concomitant mortality by Pseudomonas aeruginosa. Reintroduction of faecal bacteria and E. coli in antibiotic-treated mice establishes a high titre of E. coli in the host intestine and increases defence against P. aeruginosa colonization and morta

SUBMITTER: Christofi T 

PROVIDER: S-EPMC6783455 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature