Detection of Vasodilators From Herbal Components by a Transcriptome-Based Functional Gene Module Reference Approach.

ABSTRACT: Vasodilatation is one of the key therapeutic strategies for the treatment of various cardiovascular diseases with high blood pressure. Therefore, development of drugs assisting blood vessel dilation is promising. It has been proven that many drugs display definite vasorelaxant effects. However, there are very few studies that systemically explore the effective vasodilators. In this work, we build a transcriptome-based functional gene module reference approach for systematic pursuit of agents with vasorelaxant effects. We firstly curate two functional gene modules that are specifically involved in positive and negative regulation of vascular diameter based on the known gene functional interaction knowledge. Secondly, a collection of gene expression profiles following herbal component treatm

SUBMITTER: Li P 

PROVIDER: S-EPMC6783510 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature