Transient hysteresis and inherent stochasticity in gene regulatory networks.

ABSTRACT: Cell fate determination, the process through which cells commit to differentiated states is commonly mediated by gene regulatory motifs with mutually exclusive expression states. The classical deterministic picture for cell fate determination includes bistability and hysteresis, which enables the persistence of the acquired cellular state after withdrawal of the stimulus, ensuring a robust cellular response. However, stochasticity inherent to gene expression dynamics is not compatible with hysteresis, since the stationary solution of the governing Chemical Master Equation does not depend on the initial conditions. We provide a quantitative description of a transient hysteresis phenomenon reconciling experimental evidence of hysteretic behaviour in gene regulatory networks with inherent sto

SUBMITTER: Pajaro M 

PROVIDER: S-EPMC6783536 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature