Hemophilia A and B mice, but not VWF^-/-mice, display bone defects in congenital development and remodeling after injury.

ABSTRACT: While joint damage is the primary co-morbidity of hemophilia, osteoporosis and osteopenia are also observed. Coagulation factor VIII deficient (FVIII^-/-) mice develop an osteoporotic phenotype in the absence of induced hemarthrosis that is exacerbated two weeks after an induced joint injury. Here we have compared comprehensively the bone health of clotting factor VIII, factor IX, and Von Willebrand Factor knockout (FVIII^-/-, FIX^-/-, and VWF^-/- respectively) mice both in the absence of joint hemorrhage and following induced joint injury. We found FVIII^-/- and FIX^-/- mice, but not VWF^-/- mice, developmentally have an osteoporotic phenotype. Unilateral induced hemarthrosis causes further bone damage in both FVIII

SUBMITTER: Taves S 

PROVIDER: S-EPMC6783554 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature