Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing.

ABSTRACT:

Background

Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigated whether glutamate concentration in the dACC modulates brain response during salience processing.

Methods

Twenty-seven healthy subjects (12♀, 15♁) provided both STEAM MRS at 7T measuring glutamate concentrations in the dACC as well as a functional magnetic resonance imaging (fMRI) task to study the influence on content-related salience processing and expectedness. Salience was modulated for both sexual and non-sexual emotional photos in either expected

SUBMITTER: von During F 

PROVIDER: S-EPMC6783560 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature