In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels.

ABSTRACT: The main driving idea of the present study was the comparison between two different chemical modifications of hyaluronic acid (HA) followed by the development of nanocomposite hydrogels directly in situ by biomineralization of photocrosslinkable HA polymers through sol-gel synthesis. In this way, it has been possible to overcome some limitations due to classical approaches based on the physical blending of inorganic fillers into polymer matrix. To this aim, methacrylated and maleated HA, synthesized with similar degree of substitution (DS) were compared in terms of mechanical and physico-chemical properties. The success of in situ biomineralization was highlighted by reflect Fourier transform infrared spectroscopy and thermogravimetric analysis. Furthermore, mechanical characterization dem

SUBMITTER: D'Amora U 

PROVIDER: S-EPMC6783703 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature