Growth Rate of Escherichia coli During Human Urinary Tract Infection: Implications for Antibiotic Effect.

ABSTRACT: Escherichia coli is the primary cause of urinary tract infection (UTI), which is one of the most frequent human infections. While much is understood about the virulence factors utilized by uropathogenic E. coli (UPEC), less is known about the bacterial growth dynamics taking place during infection. Bacterial growth is considered essential for successful host colonization and infection, and most antibiotics in clinical use depend on active bacterial growth to exert their effect. However, a means to measure the in situ bacterial growth rate during infection has been lacking. Due to faithful coordination between chromosome replication and cell growth and division in E. coli, chromosome replication provides a quantitative measure of the bacterial growth rate. In thi

SUBMITTER: Haugan MS 

PROVIDER: S-EPMC6783841 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature