Sleep in Huntington's disease: a systematic review and meta-analysis of polysomongraphic findings.

ABSTRACT:

Study objectives

Disturbed overnight sleep is a prominent feature of advanced stage Huntington's disease (HD). Several polysomnography (PSG) studies have reported significant changes of sleep in HD patients, but the findings are not unequivocal. To date, no meta-analysis has investigated the PSG changes in HD patients. The present study meta-analyzed results from studies examining the PSG changes in HD patients compared with controls.

Methods

A literature search performed in MEDLINE, EMBASE, All EBM databases, PsycINFO, and CINAHL databases identified seven studies involving 152 HD patients and 144 controls which were included in our meta-analysis.

Results

Pooled results indicated decreased sleep efficiency, percentage of slow wave sleep and rapid eye movement sleep,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6783889 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature