Updated Phylogeny of Chikungunya Virus Suggests Lineage-Specific RNA Architecture.

ABSTRACT: Chikungunya virus (CHIKV), a mosquito-borne alphavirus of the family Togaviridae, has recently emerged in the Americas from lineages from two continents: Asia and Africa. Historically, CHIKV circulated as at least four lineages worldwide with both enzootic and epidemic transmission cycles. To understand the recent patterns of emergence and the current status of the CHIKV spread, updated analyses of the viral genetic data and metadata are needed. Here, we performed phylogenetic and comparative genomics screens of CHIKV genomes, taking advantage of the public availability of many recently sequenced isolates. Based on these new data and analyses, we derive a revised phylogeny from nucleotide sequences in coding regions. Using this phylogeny, we uncover the presence of several distinct lineage

SUBMITTER: Schneider AB 

PROVIDER: S-EPMC6784101 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature