Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes.

ABSTRACT:

Background

Accumulating evidence has shown that type 2 diabetes (T2D) and coronary artery disease (CAD) may stem from a 'common soil'. The aim of our study was to examine the association between genetic predisposition to T2D and the risk of severe CAD among patients with acute coronary syndromes (ACS) undergoing angiography.

Methods

The current case-control study included 1414 ACS patients with at least one major epicardial vessel stenosis > 50% enrolled in the ACS Genetic Study. The severity of CAD was quantified by the number of coronary arteries involved. Genetic risk score (GRS) was calculated using 41 common variants that robustly associated with increased risk of T2D in East Asians. Logistic regression models were used to estimate the association between GRS and the se

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC6784340 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature