Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring.

ABSTRACT: BACKGROUND:Pulmonary complications of sickle cell disease (SCD) contribute to excess morbidity and mortality. The burden of pulmonary dysfunction among Nigerians with SCD has not been well elucidated. OBJECTIVES:The objectives of this study are to describe the frequency and pattern of spirometry abnormalities in SCD and to explore the association between pulmonary dysfunction and selected parameters. METHODS:A cross-sectional study among adolescents and adults with SCD attending a University Teaching Hospital and healthy age- and gender-matched controls. Respiratory symptoms, oxygen saturation, spirometry, complete blood counts, and fetal hemoglobin (Hb) were measured. RESULTS:A total of 245 participants with SCD and 216 controls were included in the study. Frequency of respiratory symptom

SUBMITTER: Ozoh OB 

PROVIDER: S-EPMC6784438 | biostudies-literature | 2019 Oct-Dec

REPOSITORIES: biostudies-literature