Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex.

ABSTRACT: Background: The eukaryotic endomembrane system most likely arose via paralogous expansions of genes encoding proteins that specify organelle identity, coat complexes and govern fusion specificity. While the majority of these gene families were established by the time of the last eukaryotic common ancestor (LECA), subsequent evolutionary events has moulded these systems, likely reflecting adaptations retained for increased fitness. As well as sequence evolution, these adaptations include loss of otherwise canonical components, the emergence of lineage-specific proteins and paralog expansion. The exocyst complex is involved in late exocytosis and additional trafficking pathways and a member of the complexes associated with tethering containing helical rods (CATCHR) tethering co

SUBMITTER: Boehm C 

PROVIDER: S-EPMC6784791 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature