Association Between Rotavirus Vaccination and Risk of Intussusception Among Neonates and Infants: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The conclusions from the multiple randomized clinical trials exploring the relationship between development of intussusception and rotavirus vaccination among neonates and infants have been controversial.

Objective

To evaluate the association between rotavirus vaccination and risk of intussusception.

Data sources

For this systematic review and meta-analysis, PubMed, Web of Science, Cochrane library, and Embase databases were searched from January 1, 1999, through December 31, 2018, using no language restrictions. The search terms were rotavirus or RV (rotavirus vaccine) or HRV (human rotavirus vaccine), vaccin*, and intussusception.

Study selection

Randomized clinical trials of neonates and infants that compared the risk of intussusception after the

SUBMITTER: Lu HL 

PROVIDER: S-EPMC6784808 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature