Genome organization and DNA accessibility control antigenic variation in trypanosomes.

ABSTRACT: Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to evade the immune responses of their hosts. These include antigenic variation, through which an infecting organism prevents clearance by periodically altering the identity of proteins that are visible to the immune system of the host¹. Antigenic variation requires large reservoirs of immunologically diverse antigen genes, which are often generated through homologous recombination, as well as mechanisms to ensure the expression of one or very few antigens at any given time. Both homologous recombination and gene expression are affected by three-dimensional genome architecture and local DNA accessibility^2,3. Factors that link three-dimensional genome architecture, local chromatin

SUBMITTER: Muller LSM 

PROVIDER: S-EPMC6784898 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature