Functional brain networks in never-treated and treated long-term Ill schizophrenia patients.

ABSTRACT: This study compared the topological organization of brain function in never-treated and treated long-term schizophrenia patients. In a cross-sectional study, 21 never-treated schizophrenia patients with illness duration over 5 years, 26 illness duration-matched antipsychotic-treated patients and 24 demographically-matched healthy controls underwent a resting-state functional magnetic resonance imaging (MRI) scan. The topological properties of brain functional networks were compared across groups, and then we tested for differential age-related effects in regions with significant group differences. Both never-treated and antipsychotic-treated schizophrenia patient groups showed altered nodal centralities in left pre-/postcentral gyri relative to controls. Never-treated patients demonstrated

SUBMITTER: Yao L 

PROVIDER: S-EPMC6784906 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature