Xenopus embryonic spinal neurons express potassium channel Kvbeta subunits.

ABSTRACT: Developmental regulation of voltage-dependent delayed rectifier potassium current (I(Kv)) of Xenopus primary spinal neurons regulates the waveform of the action potential. I(Kv) undergoes a tripling in density and acceleration of it activation kinetics during the initial day of its appearance. Another voltage-dependent potassium current, the A current, is acquired during the subsequent day and contributes to further shortening of the impulse duration. To decipher the molecular mechanisms underlying this functional differentiation, we are identifying potassium channel genes expressed in the embryonic amphibian nervous system. Potassium channels consist of pore-forming (alpha) as well as auxiliary (beta) subunits. Here, we report the primary sequence, developmental localization, and function

SUBMITTER: Lazaroff MA 

PROVIDER: S-EPMC6784936 | biostudies-literature | 1999 Dec

REPOSITORIES: biostudies-literature