Evidence that neuropsychological deficits following early life adversity may underlie vulnerability to depression.

ABSTRACT: Early life adversity (ELA) is a risk factor for major depressive disorder (MDD), however the underlying mechanisms are not well understood. Clinical studies suggest that negative affective biases (the process, whereby cognitive processes such as learning and memory and decision-making are modified by emotional state) represent a vulnerability factor for MDD. In this study we investigate the impact of ELA on affective biases and reward-associated behaviours in rats. Sprague Dawley rat pups underwent 14 days of postnatal maternal separation (180 min/day from postnatal day 1: MS180) whilst control pups remained unhandled. In adulthood, affective biases associated with reward learning and decision-making were assessed using the affective bias test (ABT), or judgement bias task (JBT) respective

SUBMITTER: Stuart SA 

PROVIDER: S-EPMC6784985 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature