Influence of Δ9-tetrahydrocannabinol on long-term neural correlates of threat extinction memory retention in humans.

ABSTRACT: The neural mechanisms and durability of Δ9-tetrahydrocannabinol (THC) impact on threat processing in humans are not fully understood. Herein, we used functional MRI and psychophysiological tools to examine the influence of THC on the mechanisms of conditioned threat extinction learning, and the effects of THC on extinction memory retention when assessed 1 day and 1 week from learning. Healthy participants underwent threat conditioning on day 1. On day 2, participants were randomized to take one pill of THC or placebo (PBO) 2-h before threat extinction learning. Extinction memory retention was assessed 1 day and 1 week after extinction learning. We found that THC administration increased amygdala and ventromedial prefrontal cortex (vmPFC) activation during early extinction learning with no

SUBMITTER: Hammoud MZ 

PROVIDER: S-EPMC6784991 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature