Neural predictors of treatment response to brain stimulation and psychological therapy in depression: a double-blind randomized controlled trial.

ABSTRACT: Standard depression treatments, including antidepressant medication and cognitive behavioural therapy (CBT), are ineffective for many patients. Prefrontal transcranial direct current stimulation (tDCS) has been proposed as an alternative treatment, but has shown inconsistent efficacy for depression, and its mechanisms are poorly understood. We recruited unmedicated patients with major depressive disorder (N = 71 approached; N = 39 randomised) for a mechanistic, double-blind, randomized controlled trial consisting of eight weekly sessions of prefrontal tDCS administered to the left prefrontal cortex prior to CBT. We probed (1) whether tDCS improved the efficacy of CBT relative to sham stimulation; and (2) whether neural measures predicted clinical response. We found a modest and non-signifi

SUBMITTER: Nord CL 

PROVIDER: S-EPMC6784995 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature