Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

ABSTRACT: Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying biological mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, includin

SUBMITTER: Li H 

PROVIDER: S-EPMC6785001 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature