Neural and behavioral effects of oxytocin administration during theory of mind in schizophrenia and controls: a randomized control trial.

ABSTRACT: Social cognitive impairments, including theory of mind (ToM), in schizophrenia more strongly predict functional outcomes than psychotic symptoms or nonsocial cognitive deficits. Despite their clinical importance, current medications do not improve these deficits. The current study investigated the hypothesis that oxytocin, a neuropeptide implicated in social behavior, would normalize neural abnormalities in schizophrenia during ToM, and that this normalization would correlate improvement in ToM behavior. In this cross-over, double-blind, and placebo-controlled functional magnetic resonance imaging study, a single dose of 40 IU of oxytocin was administered via nasal spray to male individuals with a schizophrenia spectrum disorder (schizophrenia and schizoaffective disorder, n = 23) and heal

SUBMITTER: De Coster L 

PROVIDER: S-EPMC6785003 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature