Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.

ABSTRACT: Stress is a leading risk factor for the onset and recurrence of major depression. Enhancing stress resilience may be a therapeutic strategy to prevent the development of depression in at-risk populations or its recurrence in depressed patients. Group II metabotropic glutamate receptor (mGlu_2/3) antagonists have been recognized for antidepressant-like actions in preclinical models, but have not been evaluated for prophylactic effects. We assessed the role of mGlu_2/3 in modulating stress resilience using subtype-specific knockout mice lacking mGlu₂ (Grm2^-/-) or mGlu₃ (Grm3^-/-), and pharmacological manipulations of mGlu_2/3 activity during or prior to the induction and reinstatement of stress-induced behavioral defici

SUBMITTER: Highland JN 

PROVIDER: S-EPMC6785136 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature